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Genome rearrangements and non-coding RNAs

Team leader: 
Robert Gromadka
Team members: 
Jacek Nowak
Julita Gruchota
Kamila Maliszewska-Olejniczak
Institute or University: 
Institute of Biochemistry and Biophysics, PAS
Pawinskiego 5a
Research interests: 

The general goal of our research is to understand the epigenetic mechanisms involved in the specific recognition and elimination of large number of different sequences during macronuclear development. We are engaged in identification of proteins participating in the control of DNA rearrangements by non-coding transcripts (ncRNAs) in Paramecium tetraurelia. Our present project involves in-depth study of factors potentially involved in reprogramming of RNA synthesis machinery from coding to non-coding transcription. We postulate that some of Paramecium transcription factors may have a role in establishment of non-coding transcription by changing promoter specificity, termination signal sensitivity or processivity of RNA Polymerase II.

genome rearrangements
non-coding RNA
transcription factors
  • Nowak, J.K., Gromadka, R., Juszczuk, M., Jerka-Dziadosz, M., Maliszewska, K., Mucchielli, M.H., Gout, J.F., Arnaiz, O., Agier, N., Tang, T., Aggerbeck, L.P., Cohen, J., Delacroix, H., Sperling, L., Herbert, C.J., Zagulski, M., Bétermier, M. (2011). Functional study of genes essential for autogamy and nuclear reorganization in Paramecium. Eukaryot Cell 10, 363–372.
  • Aury, J-M., Jaillon, O., Duret, L., Noel, B., Jubin, C., Porcel, B.M., Ségurens, B., Daubin, V., Anthouard, V., Aiach, N., Arnaiz, O., Billaut, A., Beisson, J., Blanc, I., Bouhouche, K., Câmara, F., Duharcourt, S, Guigo, R., Gogendeau, D., Katinka, M., Keller, A-M., Kissmehl, R., Klotz, C., Koll, F., Le Mouël, A., Lepère, G., Malinsky, S., Nowacki, M., Nowak, J.K., Plattner, H., Poulain, J., Ruiz, F., Serrano, V., Zagulski, M., Dessen, D., Bétermier, M., Weissenbach, J., Scarpelli, C., Schächter, V., Sperling, .L, Meyer, E., Cohen, J. & Wincker, P. (2006). Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia. Nature 444, 171–178.
  • Zagulski, M. Nowak, J.K., Le Mouel, A., Nowacki, M., Migdalski, A., Gromadka, R., Noel, B., Blanc, I., Dessen, P., Wincker, P., Keller, A.-M., Cohen, J., Meyer, E., Sperling, L. (2004). High coding density on the largest Paramecium tetraurelia somatic chromosome. Curr Biol 14, 1397–1404.

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